Identification and systematic annotation of tissue-specific differentially methylated regions using the Illumina 450k array
نویسندگان
چکیده
منابع مشابه
Probe Lasso: A novel method to rope in differentially methylated regions with 450K DNA methylation data
The speed and resolution at which we can scour the genome for DNA methylation changes has improved immeasurably in the last 10years and the advent of the Illumina 450K BeadChip has made epigenome-wide association studies (EWAS) a reality. The resulting datasets are conveniently formatted to allow easy alignment of significant hits to genes and genetic features, however; methods that parse signi...
متن کاملAn integrated resource for genome-wide identification and analysis of human tissue-specific differentially methylated regions (tDMRs).
We report a novel resource (methylation profiles of DNA, or mPod) for human genome-wide tissue-specific DNA methylation profiles. mPod consists of three fully integrated parts, genome-wide DNA methylation reference profiles of 13 normal somatic tissues, placenta, sperm, and an immortalized cell line, a visualization tool that has been integrated with the Ensembl genome browser and a new algorit...
متن کاملIdentification of differentially methylated regions (DMRs) of neuronatin in mice
BACKGROUND Neuronatin (NNAT) is a paternal-inherited imprinted gene, first discovered in the rat neonatal brain, where it plays vital roles for neuronal growth, brain development, and metabolic regulation. The maternal imprint of NNAT has been identified in mice; however, the differentially methylated regions (DMRs) involved in the monoallelic expression of NNAT have not yet been investigated. ...
متن کاملAssociation of tissue-specific differentially methylated regions (TDMs) with differential gene expression.
Early studies proposed that DNA methylation could have a role in regulating gene expression during development [Riggs, A.D. (1975) Cytogenet. Cell Genet. 14, 9-25]. However, some studies of DNA methylation in known tissue-specific genes during development do not support a major role for DNA methylation. In the results presented here, tissue-specific differentially methylated regions (TDMs) were...
متن کاملBisulfighter: accurate detection of methylated cytosines and differentially methylated regions
Analysis of bisulfite sequencing data usually requires two tasks: to call methylated cytosines (mCs) in a sample, and to detect differentially methylated regions (DMRs) between paired samples. Although numerous tools have been proposed for mC calling, methods for DMR detection have been largely limited. Here, we present Bisulfighter, a new software package for detecting mCs and DMRs from bisulf...
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ژورنال
عنوان ژورنال: Epigenetics & Chromatin
سال: 2013
ISSN: 1756-8935
DOI: 10.1186/1756-8935-6-26